Platform Leads

Affiliations

Platform Lead for Cancer Databases & Tissue Banks, & Impact & Population Health, Singapore Translational Cancer Consortium;

Senior Consultant (Medical Oncology), National Cancer Centre Singapore (NCCS);

Director of Research, Clinical Analytics, Division of Medical Oncology, NCCS, Singhealth;

Senior Clinician Scientist, Genome Institute of Singapore, A*Star

Profile

Assoc. Professor Iain Tan is a Senior Consultant Medical Oncologist, leading the colorectal cancer service in the GI Oncology Team at the Department of Medical Oncology, National Cancer Centre Singapore. He co- chairs Singhealth’s multidisciplinary colorectal cancer tumor board. Nationally, he chairs the Medical Oncology Exit Exam committee for specialist accreditation & is a member of MOH’s research training review panel & NMRC’s grant review panel. At NCCS, he is also the clinical chair for NCCS’s luminal GI cancer Comprehensive Research Program. Concurrently, he is a clinician scientist at Genome Institute of Singapore and an assistant professor at Duke-NUS. His research focuses –on metastases and drug resistance and immune-oncology in gastrointestinal cancers, with a special interest in non-invasive diagnostics & innovative early phase clinical trials. He has published widely, with many first or corresponding authorpublications in leading journals including Journal of Clinical Oncology, Nature Medicine, Nature Genetics, Science Translational Medicine and Lancet Oncology. For his research, he has received the ASCO Young Investigator Award (2010) and ASCO Merit Award (2011) and Singhealth Distinguished Young Researcher Award. For his clinical service & research, he received the Singapore Youth Award in 2014, the country’s highest award for youths.

Selected Publications

Huipeng Li#, Elise T. Courtois#, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Say Li Kong, Clarinda Chua, Yongli Hu, Lawrence Wee, Lim Kiat Hon, Tan Wah Siew, Mark Wong, Paul Jongjoon Choi, Lawrence Wee, Axel M. Hillmer, Iain Beehuat Tan*, Paul Robson*, Shyam Prabhakar* (co-corresponding author) Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Human Colorectal Tumors. Nature Genetics 2017 (in press)

Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB. Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. Mol Oncol. 2017 Feb;11(2):124-139.

Ng SB, Chua C, Ng M, Gan A, Poon PS, Teo M, Fu C, Leow WQ, Lim KH, Chung A, Koo SL, Choo SP, Ho D, Rozen S, Tan P, Wong M, Burkholder WF, Tan IB. Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery. Sci Rep. 2017 Jan 19;7:40737.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TK, Fui AC, Hoong CW, Chan JK, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SE, Tan HK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DS, Tan IB, Ginhoux F, Newell EW. Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency. Immunity. 2017 Jan 17;46(1):148-161.

Fukawa T, Chua BY, Chua JM, Tan EJ, Huang D, Qian C, Ong P, Li ZM, Chen SW, Mak SY, Elsa Mohan S, Wang RR, Lim WJ, Kanayama H, Lai JH, Chua C, Ong HS, Tan KK, Ho YS, Tan IB*, The BT*, Ng SC* Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia Nature Medicine 2016 online 2 May 2016 2016 Jun;22(6):666-71. (IF 2730.3) *Co-corresponding author

Impact & Population Health

Assoc Prof Iain Tan

Assoc Prof Iain Tan