Adjunct Associate Professor Kenneth CHANG
MBChB, FRCPath
Adjunct Associate Prof Kenneth Chang  | Singapore Translational Cancer Consortium (STCC)

Cancer Databases & Tissue Banks Platform Co-Lead

Singapore Translational Cancer Consortium

Head/Senior Consultant 

Department of Pathology and Laboratory Medicine 

KK Women’s and Children’s Hospital   

Director 

SingHealth Tissue Repository  

 

Director 

Advanced Molecular Pathology Laboratory

SingHealth

Vice Chair

Clinical Service Transformation 

Pathology Academic Clinical Programme (ACP)

Visiting Consultant 

Division of Forensic Medicine, Applied Sciences Group 

Health Sciences Authority
 

Adjunct Associate Professor

Duke-NUS Graduate Medical School

Adjunct Associate Professor Kenneth Chang is senior consultant paediatric pathologist and Head of Department, Department of Pathology and Laboratory Medicine at KK Women’s and Children’s Hospital in Singapore. He is Adjunct Associate Professor at Duke-NUS Medical School, and Academic Vice-Chair for Clinical Service Innovation in the SingHealth Duke-NUS Pathology Academic Clinical Programme. He is a Principal Investigator in the VIVA-KKH Paediatric Brain and Solid Tumours Programme. He is also Director of the SingHealth Tissue Repository and Advanced Molecular Pathology Laboratory, which are core research platforms in the SingHealth Academic Medical Centre.

 

Adjunct Associate Professor Chang trained in paediatric pathology at the Hospital for Sick Children in Toronto, Canada and University of Toronto, completing a 2-year clinical fellowship from 2007 to 2009. More recently in the summer of 2015, he was a visiting fellow at the University of British Columbia and BC Cancer Agency. Currently, he is a Council Member in the International Paediatric Pathology Association, and plays a role in outreach to paediatric pathologists in the Asia-Pacific region.

 

His research interests include molecular diagnostics in relation to paediatric cancers, paediatric sarcomas with a focus on BCOR-mutated sarcomas, and placental pathology. He has published more than 80 scientific articles and 5 book chapters.

Selected Publications

  • Aw SJ, Wang S, Loh AH, Kuick CH, Lian DW, Yong MH, Ling S, Peh GL, Soh SY, Loh AH, Tan PH, Chang KT. Novel karyotypes and cyclin D1 immunoreactivity in clear cell sarcoma of the kidney. Pediatr Dev Pathol. 2015 Mar 9. [Epub ahead of print]

  • Loh TJ, Lian DW, Iyer P, Lam JC, Kuick CH, Aung AC, Chang KT. Congenital GATA1-mutated myeloproliferative disorder in trisomy 21 complicated by placental fetal thrombotic vasculopathy. Hum Pathol. 2014 Nov;45(11):2364-7.

  • Chang KT. Examination of the placenta: medico-legal implications. Semin Fetal Neonatal Med. 2014 Oct;19(5):279-84.

  • Shenje LT, Andersen P, Halushka MK, Lui C, Fernandez L, Collin GB, Amat-Alarcon N, Meschino W, Cutz E, Chang K, Yonescu R, Batista DA, Chen Y, Chelko S, Crosson JE, Scheel J, Vricella L, Craig BD, Marosy BA, Mohr DW, Hetrick KN, Romm JM, Scott AF, Valle D, Naggert JK, Kwon C, Doheny KF, Judge DP. Mutations in Alström protein impair terminal differentiation of cardiomyocytes. Nat Commun. 2014 Mar 4;5:3416.

  • Yan B, Kuick CH, Lim M, Venkataraman K, Tennakoon C, Loh E, Lian D, Leong MY, Lakshmanan M, Tergaonkar V, Sung WK, Soh SY, Chang KT. Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas. PLoS One. 2014 Sep 4;9(9):e106575.

  • Yan B, Lim M, Zhou L, Kuick CH, Leong MY, Yong KJ, Aung L, Salto-Tellez M, Chang KT. Identification of MET genomic amplification, protein expression and alternative splice isoforms in neuroblastomas. J Clin Pathol. 2013 Nov;66(11):985-91.

  • Chang KT, Keating S, Costa S, Machin G, Kingdom J, Shannon P. Third-trimester stillbirths: correlative neuropathology and placental pathology. Pediatr Dev Pathol. 2011 Sep-Oct;14(5):345-52.

  • Chang KT, Taylor GP, Meschino WS, Kantor PF, Cutz E. Mitogenic cardiomyopathy: a lethal neonatal familial dilated cardiomyopathy characterized by myocyte hyperplasia and proliferation. Hum Pathol. 2010 Jul;41(7):1002-8.

  • Chang KT. Pathological examination of the placenta: raison d'être, clinical relevance and medicolegal utility. Singapore Med J. 2009 Dec;50(12):1123-33. Review.

  • Chang KT, Rajadurai VS, Walford NQ, Hwang WS. Alveolar capillary dysplasia: absence of CD117 immunoreactivity of putative hemangioblast precursor cells. Fetal Pediatr Pathol. 2008;27(3):127-40.