Adjunct Associate Professor Chee Cheng Ean

Affiliations

• Impact & Population Health Platform Lead, Singapore Translational Cancer Consortium

• Executive Director, National University Cancer Institute, Singapore

• Adjunct Associate Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

• Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore

Profile

Adj A/Prof Chee Cheng Ean is the Executive Director of the National University Cancer Institute, Singapore. In this role, she provides leadership and direction, and is responsible for implementing strategic initiatives for NCIS (pronounced N-CIS), which is the only public, academic cancer center in Singapore treating both pediatric and adult cancers in one facility. Adj A/Prof Chee is also a senior consultant, gastrointestinal (GI) oncologist and clinician investigator. Her portfolio includes clinical and research initiatives in precision oncology and clinical trials involving novel therapeutics in GI cancers which have been awarded institutional and national grant funding. She also leads the cancer survivorship programme at NCIS and is a proponent of value-based healthcare initiatives.

Selected Publications

• Loh J, Wu J, Chieng J, Chan A, Yong WP, Sundar R, Lee SC, Wong A, Lim JSJ, Tan DSP, Soo R, Goh BC, Tai BC, Chee CE. Clinical outcome and prognostic factors for Asian patients in Phase I clinical trials. Br J Cancer. 2023 Apr;128(8):1514-1520. doi: 10.1038/s41416-023-02193-2. Epub 2023 Feb 16. PMID: 36797357; PMCID: PMC10070409.

• Chee CE, Ooi M, Lee SC, Sundar R, Heong V, Yong WP, Ng CH, Wong A, Lim JSJ, Tan DSP, Soo R, Tan JTC, Yang S, Thura M, Al-Aidaroos AQ, Chng WJ, Zeng Q, Goh BC. A Phase I, First-in-Human Study of PRL3-zumab in Advanced, Refractory Solid Tumors and Hematological Malignancies. Target Oncol. 2023 Apr 15. doi: 10.1007/s11523-023-00962-w. Epub ahead of print. PMID: 37060431.

• Bonney GK, Chew CA, Lodge P, Hubbard J, Halazun KJ, Trunecka P, Muiesan P, Mirza DF, Isaac J, Laing RW, Iyer SG, Chee CE, Yong WP, Muthiah MD, Panaro F, Sanabria J, Grothey A, Moodley K, Chau I, Chan ACY, Wang CC, Menon K, Sapisochin G, Hagness M, Dueland S, Line PD, Adam R. Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines. Lancet Gastroenterol Hepatol. 2021 Sep 7. PMID: 34506756.

• Sarker D, Plummer R, Meyer T, Sodergren M, Basu B, Chee CE, Huang KW, et al. MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial. Clin Cancer Res. 2020;26(15):3936-3946.

• Chan GHJ, Chee CE. Perioperative Chemotherapy for Liver Metastasis of Colorectal Cancer. Cancers. 2020;12(12):3535.

• Kelly RJ, Lee J, Bang YJ, Almhanna K, Blum-Murphy M, Catenacci DVT, Chung HC, Wainberg ZA, Gibson MK, Lee KW, Bendell JC, Denlinger CS, Chee CE, Omori T, et al. Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma. Clin Cancer Res. 2020;26(4):846-854.

• Chan GHJ, Chee CE. Making sense of adjuvant chemotherapy in colorectal cancer. J Gastrointest Oncol. 2019 Dec;10(6):1183-1192.

• Sundar R, Tan IBH, Chee CE. Negative Predictive Biomarkers in Colorectal Cancer: PRESSING Ahead. J Clin Oncol. 2019 Nov 20;37(33):3066-3068.

• Chee CE, Ashrani AA, Marks RS, Petterson TM, Bailey KR, Melton LJ 3rd, Heit JA. Predictors of Venous Thromboembolism Recurrence and Bleeding Among Active Cancer Patients: A Population-Based Cohort Study. Blood. 2014; 123(25): 3972-8.

• Thura M, Al-Aidaroos AQ, Gupta A, Chee CE, Lee SC, et al. PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein. Nat Commun. 2019;10(1):2484.