Professor Goh Boon Cher

Affiliations

• Cancer Clinical Trials and IMUs Platform Lead, Singapore Translational Cancer Consortium

• Deputy Director, Cancer Science Institute of Singapore, National University of Singapore

• Yong Loo Lin Professor in Medical Oncology, National University of Singapore

• Senior Consultant (Hematology-Oncology), National University Cancer Institute Singapore, National University Health System

Profile

Professor Goh Boon Cher received his undergraduate medical education at the National University of Singapore, and joined the Department of Hematology-Oncology, NUH where he completed fellowship in medical oncology, and completed a National Medical Research Council fellowship in clinical pharmacology and phase I clinical trials at the University of Chicago. Professor Goh has established himself as a leading clinician scientist in clinical pharmacology and cancer drug development, and currently serves on several institutional and national research portfolios. He has contributed much to the development of a clinical trial research infrastructure at the NCIS, one of the largest clinical research groups in Singapore, and chaired the Cancer Therapeutics Research Group, an Asia Pacific cancer research group. As a clinician, Professor Goh is well established in the fields of head and neck/lung cancer. As a senior clinician and scientist, he has mentored many clinical oncology and pharmacology fellows, and has been awarded senior clinician scientist from the Biomedical Research Council and the National Medical Research Council since 2005. In addition, he has been competitive in being awarded research grants as principal investigator of both individual project grants and infrastructure grants. Beyond cancer therapeutics, he is also widely published in pharmacogenetics, studying how human genetics affect drug response. Internationally, as a key opinion leader, he has served on advisory boards of several pharmaceutical companies advising on drug development of very novel drugs, and has served on editorial boards of important journals like the Journal of Clinical Oncology and Annals of Oncology. As a responsible member of clinical research, he has also espoused principles of ethics, and served for several terms as Chairman of the Domain Specific Research Board. 

Selected Publications  

• Hellmann MD, Kim TW, Lee CB, Goh BC , Miller WH, Oh DY, Jamal R, Chee CE, Chow LQM, Gainor JF, Desai J, Solomon BJ, Das Thakur M, Pitcher B, Foster P, Hernandez G, Wongchenko MJ, Cha E, Bang YJ, Siu LL, Bendell J. Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors. Ann Oncol. 2019 30(7):1134-1142 

• Abaza YM, Kadia TM, Jabbour EJ, Konopleva MY, Borthakur G, Ferrajoli A, Estrov Z, Wierda WG, Alfonso A, Chong TH, Chuah C, Koh LP, Goh BC , Chang JE, Durkes DE, Foudray MC, Kantarjian HM, Dong XQ, Garcia-Manero G. Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies. Cancer. 2017;123(24):4851. 

• Tai WM, Yong WP, Lim C, Low LS, Tham CK, Koh TS, Ng QS, Wang WW, Wang LZ, Hartono S, Thng CH, Huynh H, Lim KT, Toh HC, Goh BC , Choo SP. A phase Ib study of selumetinib (AZD6244, ARRY-142886) in combination with sorafenib in advanced hepatocellular carcinoma (HCC). Ann Oncol 2016;27(12):2210. 

• Wong AL, Sundar R, Wang TT, Ng TC, Zhang B, Tan SH, Soh TI, Pang AS, Tan CS, Ow SG, Wang L, Mogro J, Ho J, Jeyasekharan AD, Huang YQ, Thng CH, Chan CW, Hartman M, Iau P, Buhari SA, Goh BC , Lee SC. Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer. Oncotarget 2016 Aug 

• A. L. Wong,  R. A. Soo, D. S. Tan, S. C.  Lee,  J. S. Lim, P. C. Marban, L. R. Kong, Y. J. Lee, L. Z. Wang, W. L. Thuya, R. Soong, M. Q. Yee, T. M. Chin, M. T. Cordero, B. R. Asuncion, B. Pang, S. Pervaiz, JL Hirpara, A. Sinha, W. W. Xu, M. Yuasa, T. Tsunoda, M. Motoyama, T. Yamauchi and B. C. Goh . Phase I and biomarker study of a novel inhibitor of STAT3 phophorylation, OPB-51602 in patients with refractory solid cancers. Ann Oncol 2015;26(5):998-1005. 

• Tsao A, Hui EP, Juergens R, Marur S, Huat TE, Cher GB , Hong RL, Hong WK, Chan AT. Phase II study of TAS-106 in patients with platinum-failure recurrent or metastatic head and neck cancer and nasopharyngeal cancer. Cancer Med. 2013 Jun;2(3):351-9. 

• Lim WT, Ng QS, Percy I, Leong SS, Singh O, Chowbay B, Gao F, Thng CH, Goh BC , Tan DS, Koh TS, Toh CK, Tan EH. Phase II Study of Pazopanib in Asian Patients with Recurrent/Metastatic Nasopharyngeal Carcinoma. Clin Cancer Res 2011;17(16):5481-9. 

• Chan D, Yeo WL, Tiemsim Cordero M, Wong CI, Chuah B, SooR, Tan SH, Lim SE, Goh BC , Lee SC. Phase II study of gemcitabine and carboplatin in metastatic breast cancers with prior exposure to anthracyclines and taxanes. Invest New Drugs 2010;28(6):859-62. 

• Chiung-Ing Wong, Tong-San Koh, Ross Soo, Septian Hartono, Choon-Hua Thng, Evelyn McKeegan, Wei-Peng Yong, Chien-Shing Chen, Soo-Chin Lee, John Wong, Robert Lim, Norita Sukri, Siew-Eng Lim, Ai-Bee Ong, Joyce Steinberg, Neeraj Gupta, Rajendra Pradhan, Rod Humerickhouse, Boon-Cher Goh . Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. J Clin Oncol 2009;27(28):4718-4726. 

• Yong WP, Wang LZ, Tham LS, Wong CI, Lee SC, Soo R, Sukri N, Lee HS, Goh BC . A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers. Cancer Chemother Pharmacol 2007 Oct 2 (epub)