DIVERSITY Organoid Catalogue

A Curated Catalogue of Well-Annotated Tumour Organoid Models

Last updated on 21 October 2026

Overview

Connecting Models, Data and Discover

The Differential In-Vitro Evaluation of Resistance and Sensitivity (DIVERSITY) initiative, led by the Singapore Translational Cancer Consortium (STCC), is Singapore’s first national effort to connect patient-derived tumour organoid (PDTO) models through a curated, virtual catalogue. Bringing together organoid resources and expertise from academic, healthcare and research institutions across Singapore, DIVERSITY enables researchers and industry partners to discover and identify suitable models for collaborative research while respecting institutional governance and data-sharing requirements.

Chart shows PDO cancer types with Institutional partners NUS, National Cancer Centre Singapore, National University Hospital, and A*STAR GIS

DIVERSITY Organoid Catalogue

Breast

Catalogue of Breast PDO models, including clinical details and assay data.

ID	Primary site	Collection site	Gender	Donor age	Clinical info	H&E	WES	WGS	RNA-seq	IHC	other assays	FFPE block
STCC-BRCA-001	Breast	Breast	F	63	✓	✓	-	-	-	✓	-	✓
STCC-BRCA-002	Breast	Brain	F	56	✓	✓	-	-	-	✓	-	✓
STCC-BRCA-003	Breast	Breast	F	83	✓	✓	-	-	-	-	-	✓
STCC-BRCA-004	Breast	Breast	F	85	✓	✓	-	-	-	✓	-	✓
STCC-BRCA-005	Breast	PE	F	40	✓	✓	-	-	-	✓	-	✓
STCC-BRCA-006	Breast	Breast	F	30	✓	✓	-	-	-	✓	-	✓
STCC-BRCA-007	Breast	PE	F	78	✓	✓	-	-	-	-	-	✓
STCC-BRCA-008	Breast	Breast	F	40	✓	✓	-	-	-	-	-	✓
^{Abbreviations:} ^{PE - Pleural Effusion, M - Male, F - Female, H&E - Haematoxylin and Eosin, WES - Whole Exome Sequencing, WGS - Whole Genome Sequencing, RNA-seq - RNA sequencing, IHC - Immunohistochemistry, FFPE - Formalin-Fixed Paraffin-Embedded}

Colorectal

Catalogue of Colorectal Cancer (CRC) PDO models, including clinical details and assay data.

ID	Primary site	Collection site	Gender	Donor age	Clinical info	H&E	WES	WGS	RNA-seq	IHC	other assays	FFPE block
STCC-CRC-001	Colon	Liver	F	61	✓	✓	-	-	-	✓	-	✓
STCC-CRC-002	Colon	Colon	M	45	✓	-	✓	✓	✓	-	✓	-
STCC-CRC-003	Colon	Colon	F	41	✓	✓	✓	-	-	✓	-	✓
STCC-CRC-004	Colon	Colon	F	73	✓	✓	✓	-	-	✓	-	✓
STCC-CRC-005	Rectum	Rectum	F	47	✓	✓	✓	-	-	✓	-	✓
STCC-CRC-006	Colon	Ovary	F	41	✓	✓	✓	-	-	✓	-	✓
STCC-CRC-007	Colon	Ovary	F	73	✓	✓	✓	-	-	✓	-	✓
STCC-CRC-008	Rectum	Liver	F	47	✓	✓	✓	-	-	✓	-	✓
^{Abbreviations:} ^{M - Male, F - Female, H&E - Haematoxylin and Eosin, WES - Whole Exome Sequencing, WGS - Whole Genome Sequencing, RNA-seq - RNA sequencing, IHC - Immunohistochemistry, FFPE - Formalin-Fixed Paraffin-Embedded}

Gastric

Catalogue of Gastric PDO models, including clinical details and assay data.

ID	Primary site	Collection site	Gender	Donor age	Clinical info	H&E	WES	WGS	RNA-seq	IHC	other assays	FFPE block
STCC-GS-001	Stomach	Stomach	M	60	✓	✓	✓	✓	✓	✓	✓	✓
STCC-GS-002	Stomach	Stomach	M	40	✓	-	✓	✓	✓	✓	✓	✓
STCC-GS-003	Stomach	Stomach	F	68	✓	-	✓	✓	✓	✓	✓	✓
STCC-GS-004	Stomach	Stomach	M	63	✓	-	✓	✓	✓	✓	✓	✓
STCC-GS-005	Stomach	Stomach	M	58	✓	✓	✓	✓	✓	✓	✓	✓
STCC-GS-006	Stomach	Stomach	M	81	✓	-	-	-	-	-	-	-
STCC-GS-007	Stomach	Stomach	M	47	✓	-	✓	✓	✓	✓	✓	-
STCC-GS-008	Stomach	Liver	F	46	✓	✓	✓	✓	✓	✓	✓	✓
STCC-GS-009	Stomach	Stomach	M	59	✓	✓	-	-	✓	-	-	✓
STCC-GS-010	GEJ	GEJ	M	59	✓	✓	✓	✓	✓	✓	✓	✓
STCC-GS-011	Stomach	Stomach	M	33	✓	✓	✓	✓	✓	✓	✓	✓
STCC-GS-012	Stomach	Stomach	M	52	✓	-	✓	✓	✓	✓	✓	-
STCC-GS-013	Stomach	Stomach	F	69	✓	-	✓	✓	-	✓	✓	-
^{Abbreviations:} ^{GEJ - Gastroesophageal Junction, M - Male, F - Female, H&E - Haematoxylin and Eosin, WES - Whole Exome Sequencing, WGS - Whole Genome Sequencing, RNA-seq - RNA sequencing, IHC - Immunohistochemistry, FFPE - Formalin-Fixed Paraffin-Embedded}

Other

Catalogue of PDO models from other cancer types, including clinical details and assay data.

Cancer type	ID	Primary site	Collection site	Gender	Donor age	Clinical info	H&E	WES	WGS	RNA-seq	IHC	other assays	FFPE block
Cholangio	STCC-CCA-001	-	-	-	-	-	✓	-	-	-	✓	-	✓
Gallbladder Neuroendocrine	STCC-GB-001	Gallbladder	Gallbladder	F	65	✓	✓	-	-	-	✓	-	✓
Pancreatic	STCC-PDAC-001	Pancreas	Pancreas	F	77	✓	✓	-	-	-	-	-	✓
Pancreatic	STCC-PDAC-002	Pancreas	Pancreas	F	61	✓	✓	✓	-	-	✓	-	✓
^{Abbreviations:} ^{M - Male, F - Female, H&E - Haematoxylin and Eosin, WES - Whole Exome Sequencing, WGS - Whole Genome Sequencing, RNA-seq - RNA sequencing, IHC - Immunohistochemistry, FFPE - Formalin-Fixed Paraffin-Embedded}

Why Organoids? Why New Approach Methodologies (NAMs)?

As the biomedical research community advances towards more human-relevant preclinical models, New Approach Methodologies (NAMs) are transforming the way diseases are studied and therapies are developed. Recent regulatory developments, including the U.S. Food and Drug Administration (FDA)'s support for validated NAMs and alternatives to animal testing, have further accelerated the adoption of human-relevant models in drug discovery and development. Patient-derived organoids retain key biological characteristics and the heterogeneity of human tumours, providing a powerful platform to investigate cancer biology, understand treatment resistance, and evaluate therapeutic responses in a more clinically relevant setting.

DIVERSITY consolidates well-annotated patient-derived organoid models with comprehensive molecular profiling and de-identified clinical annotations into a single national platform, enhancing model visibility and enabling multi-institutional research collaboration. As Singapore's first national PDTO catalogue, DIVERSITY serves as a valuable resource for researchers, clinicians, and industry partners seeking access to clinically relevant cancer models. Through this platform, STCC aims to accelerate translational cancer research, foster academia-industry partnerships, and advance innovative diagnostics, therapeutics, and precision oncology strategies that bring research discoveries closer to clinical impact.